Drug Side Effects
Sitagliptin is a conventionally-used medication that is used to lower blood sugar levels in people suffering from type 2 diabetes. Sitagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. Like all medications, Sitagliptin side effects are caused by the way the drug works in the body.
Diabetics have high blood sugar because they either
Sitagliptin lowers blood sugar in the body by:
When we have just eaten, chemicals called Incretins stimulate the pancreas to produce more insulin. After Incretins have done their job, an enzyme called DPP-4 acts to break them down. Sitagliptin inhibits DPP-4, allowing incretins to stimulate the pancreas to produce insulin for longer. It also slows down digestion and decreases appetite for longer. This results in a more gradual absorption of glucose from the food and lowering blood sugar levels.
Sitagliptin and other DPP-4 inhibitors are a new class of drugs, often used only as the second or third line of attack. They are chosed only when metformin or sulfonylureas have been found to be ineffective in reducing blood sugar. They are considered by by many doctors to be an alternative to thiazolidinediones or TZDs.
Januvia, Galvus, Onglyza, Icandra and Jalra
Sitagliptin can cause several side effects and the severity differs from person to person.
The most common Sitagliptin side effects include diarrhea, nausea and abdominal pains. Slower passage of food from the stomach to the colon can lead to heaviness, improper digestion and pains in the digestive tract, especially in the colon.
One of the major Sitagliptin side effects, and of other gliptins, is due to its action on glucagon. Glucagon is a hormone that increases blood sugar levels. Sitagliptin reduces the action of glucagon. Since this medication is often used in combination with metformin or sulfonylureas to control blood sugar, the combined action of all the medicines may reduce reduce your blood sugar levels dangerously. This condition is called hypoglycemia. Confusion, palpitations, shaking, nausea, excessive sweating and hunger are classic symptoms of hypoglycemia.
Some allergic skin reactions may also be observed, including purple patches on the skin. Symptoms of the flu, such as stuffy nose, sneezing and sore throat are also seen in patients who are on Sitagliptin.
By fine-tuning your dosage, the doctor can take care of your initial digestive distress.
Many prescription drugs interfere with the way nutrients are absorbed from food in the human body. This is called drug-nutrient depletion. Since Gliptins are relatively new to the market, they have not been studied for nutrient depletion that they may cause over a longer period of use.
If you are taking any of the drugs below, be sure to inform the doctor:
Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
Make sure to follow all diet and exercise recommendations made by your doctor or dietician.
Sitagliptin, like other drugs, interacts with other prescription drugs that you may be taking at that time. Some of these could be harmful. Please inform your healthcare practitioner about your medication history and prescription / over-the-counter drugs they have taken in past or are currently taking.
Digoxin is a drug which which should be cautiously used while taking Januvia. Sitagliptin may slightly increase the concentration of digoxin (Lanoxin) in the body when both drugs are being taken. Digoxin concentrations should be monitored appropriately.
Do not take Januvia if:
You are allergic to any of the ingredients in Januvia. Symptoms of a serious allergic reaction to Januvia may include rash, raised red patches on your skin (hives), or swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing.
Active ingredient: Sitagliptin
Inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate. The tablet film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and yellow iron oxide.
Today, M.D.s like Dr.Jason Fung are saying that type 2 diabetes is reversible. On of the key components of this is eating the right diabetic diet. Despite being on medications, you could suffer from complications.
Dietary supplements that have been studied to help with controlling blood sugar could assist you in reducing the burden of your prescription drugs.
Research is increasingly showing that diet and lifestyle changes – including intermittent fasting, yoga, meditation, weight loss and moderate exercise – can have a huge positive impact on diabetes. You should explore all of these avenues, to get the best results for yourself.